首页工具

登录

搜索结果

Search Results for " neutrophil elastase "

Targets Recommended: Others

48

抑制剂 & 化合物

2

天然产物

3

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T9964	BOS-318	Others	Others
	BOS-318是一种Furin 抑制剂，具有缓慢解离，高选择性，细胞通透性等特点。
T79397	Neutrophil elastase inhibitor 4
	Neutrophilelastase inhibitor4 (compound 4f) 是竞争性抑制HNE的化合物，具有较低的半抑制浓度(IC50: 42.30 nM)和解离常数(Ki: 8.04 nM)。此外，该化合物能够诱导T47D细胞的apoptosis，并在多种细胞系中展现出抗增殖作用，分别在T47D、RPMI 8226、A549、HSF细胞系的IC50值为21.25、34.17、29.93、99.11 nM。
T13389	ZD-0892	PI3K	PI3K/Akt/mTOR signaling
	ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectively).
T6986	Sivelestat ONO5046,EI546,西维来司他,LY544349	Others; SARS-CoV; Serine Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂，其 IC50值为 44 nM，Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。
T3107	Alvelestat AZD9668,Avelestat	Others; Serine Protease	Others; Proteases/Proteasome
	Alvelestat (AZD9668) 是一种口服活性，亲和性和选择性的中性粒细胞弹性蛋白酶 (NE) 抑制剂，pIC50=7.9 nM，Ki=为 9.4 nM，Kd=9.5 nM。
T8563	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one	Serine Protease	Proteases/Proteasome
	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one 是一种人类中性粒细胞弹性蛋白酶抑制剂。
T12613L	BAY-85-8501	Serine Protease	Proteases/Proteasome
	BAY-85-8501 是选择性的人类中性脂酶抑制剂，IC50=65 pM。
T68099	midesteine MR-889	Others	Others
	Midesteine (MR-889) 是一种可逆、慢结合、完全竞争的蛋白酶抑制剂。
T8602	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE	Serine Protease	Proteases/Proteasome
	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE 靶向中性粒细胞弹性蛋白酶（人）。
T10473	BAY-678	Others	Others
	BAY-678是一种人中性粒细胞弹性蛋白酶（HNE；IC50：20 nM）抑制剂，具有口服生物活性、高效性和选择性。BAY-678 是被基因结构组学联盟 (SGC) 推荐的化学探针。
T25131	AZD8309 AZD 8309,AZD-8309	Glutathione Peroxidase; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism
	AZD8309 是一种强效的、可口服的趋化因子受体CXCR2的拮抗剂，能够调节中性粒细胞的转运，可显著降低胰腺和肺部的MPO，并降低胰腺内的胰蛋白酶和弹性蛋白酶活性。AZD8309 能够用于研究炎症系列疾病。
T20762	Sivelestat sodium tetrahydrate ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046	Serine Protease	Proteases/Proteasome
	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其 IC50 值为 44 nM， Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。
T15285	FK706	Serine Protease	Proteases/Proteasome
	FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef
T10254	AE-3763	Serine Protease	Proteases/Proteasome
	AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
T17288	ZD8321	Serine Protease	Proteases/Proteasome
	ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
T31877	Freselestat ONO-PO 736,ONO-6818,ONO 6818,ONO6818
	Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.
T25520	ICI 200355 ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355
	ICI 200355 is an inhibitor of human neutrophil elastase.
T25782	MDL 27324 MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324
	MDL 27324 is an inhibitor of human neutrophil elastase.
T25781	MDL 101146 MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146
	MDL 101146 is an orally active neutrophil elastase inhibitor.
T11525L	GW311616 hydrochloride GW311616A	Others	Others
	GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
T69790	GW-475151
	GW-475151 inhibits human neutrophil elastase (HNE).
T25518	Ici 186756 Ici186756,Ici--186756
	Ici 186756 is a novel, effective, and selective inhibitor of human neutrophil elastase.
T25784	MDL-101146, (R)- MDL101146, (R)-
	MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.
T3107L	Alvelestat tosylate
	Alvelestat can inhibit neutrophil elastase (NE), which acts an important role in NET formation.
T25521	Ici 200880 Ici 200,880,Ici-200880,Ici200,880,Ic-200,880,Ici200880
	Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.
T25784L	MDL-101146, (S)- MDL101146, (S)-
	MDL-101146, (S)- is an effective orally active inhibitor of human neutrophil elastase.
T27747	KRP-109 KRP 109,KRP109
	KRP-109, a neutrophil elastase (NE) inhibitor, acts by decreasing expression of TGF-ß Signal Related Genes.
T11525	GW311616	Others	Others
	GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
T28244	Ono EI-601 OnoEI601,Ono-EI 601,Ono-EI-601
	Ono EI-601 is the main metabolite of ONO-5046, the human neutrophil elastase inhibitor .
T41043	Lonodelestat POL6014
	Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE).
T11865	Lodelaben 氯德拉苯,SC-39026,Declaben	Others	Others
	Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
T68240	AZD-9819
	AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease (COPD).
T21414	Sivelestat sodium ONO 5046,LY-544349,Sivelestat sodium salt,ONO-5046,ONO5046,西维来司钠,LY544349,LY 544349
	Sivelestat, an inhibitor of human neutrophil elastase, is used in the treatment of acute respiratory failure. Preliminary studies show Sivelestat may improve neuropathic pain.
T19202	BAY-678 racemate	Others	Others
	BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, selective and cell-permeable inhibitor of human neutrophil elastase (HNE; IC50: 20 nM).
T80553	MeOSuc-AAPA-CMK
	MeOSuc-AAPA-CMK为一种针对人中性粒细胞弹性蛋白酶 (elastase) 的高效抑制剂。
T62846	Freselestat quarterhydrate
	Freselestat quarterhydrate (ONO-6818 quarterhydrate) 是一种有效的、口服具有活力的嗜中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂 (Ki: 12.2 nM)。Freselestat quarterhydrate 对其他蛋白酶（例如胰蛋白酶，蛋白酶3，胰弹性蛋白酶，凝血酶，纤溶酶，胶原酶，组织蛋白酶G 和鼠巨噬细胞弹性蛋白酶）的活性低 100 倍以上，表现出有效的抗炎作用。
T38363	MeOSuc-AAPV-pNA
	Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by b...
T72111	Ala-Ala-Pro-Val-chloromethylketone AAPV-CMK
	Ala-Ala-Pro-Val-chloromethylketone 是不可逆的 NE 抑制剂，适用于慢性炎症性气道疾病研究。
T12613	(R)-BAY-85-8501	Others	Others
	(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent Human Neutrophil Elastase (HNE)inhibitor(IC50 of 65 pM).
T73657	Tiprelestat
	Tiprelestat为有效的人类中性粒细胞弹性蛋白酶(elastase)抑制剂，展现抗菌及抗炎活性，适用于炎症/免疫疾病研究。
T36339	Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp
	Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm; em = 420 nm).
T76248	Tutuilamide A
	Tutuilamide A为一有效抑制剂，针对猪胰弹性蛋白酶(PPE)展现出1.2 nM的IC50值。此外，该化合物亦对人中性粒细胞弹性蛋白酶(HNE; IC50=0.73 nM)及激肽释放酶7(KLK7; IC50=5.0 nM)有抑制作用。
T76216	Lonodelestat TFA
	Lonodelestat TFA (POL6014 TFA) 是一种有效的、口服活性的、选择性的肽类hNE抑制剂，展现了治疗囊性纤维化(CF)的潜力。
T10473L	BAY-677	Others	Others
	BAY-677, serving as an inactive control for BAY-678, is distinguished by BAY-678's capabilities as an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), showcasing a high potency with an IC50 of 20 nM[1]. Furthermore, BAY-678 has been publicly nominated as a chemical probe by the Structural Genomics Consortium (SGC)[2].
T79496	Cathepsin C-IN-6
	CathepsinC-IN-6 (compound 2) 是基于E-64c-肼的cathepsin C抑制剂，展现抗炎活性。能有效抑制中性粒细胞弹性蛋白酶的激活，对于中性粒细胞浓度高的炎症性疾病（例如慢性阻塞性肺疾病）有潜在治疗作用。
T73532	JO146
	JO146为针对沙眼衣原体高温需要蛋白A(CtHtrA)的蛋白酶抑制剂，其对CtHtrA和人中性粒细胞弹性蛋白酶(HNE)的IC50值分别为21.86 μM和1.15 μM，可应用于细菌感染的抑制。
T21989	SSR 69071
	SSR69071 是一种有效的，具有口服活性的选择性中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂。SSR69071 对人弹性蛋白酶 (Ki=0.0168 nM) 的亲和力高于对大鼠 (Ki=3 nM)、小鼠 (Ki=1.8 nM) 和兔 (Ki=58 nM) 弹性蛋白酶。SSR69071 减少缺血再灌注损伤后的心肌梗死面积。SSR69071 还具有治疗慢性阻塞性肺病、哮喘、肺气肿、囊性纤维化和多种炎症性疾病的潜力。
T80254	Elafin(human)
	Elafin，亦称为ESI（elafin-specific inhibitor）或SKALP（skin anti-leucoprotease），为一种低分子量抑制剂，专一性地抑制肺部中性粒细胞中的HNE（人中性粒细胞弹性蛋白酶）和proteinase 3。同时，Elafin对Pseudomonas aeruginosa和Staphylococcus aureus亦具有抗生素效果。

化合物

Cat.No: T9964

Target: Others

Neutrophil elastase inhibitor 4

Cat.No: T79397

Cat.No: T13389

Target: PI3K

Cat.No: T6986

Synonym: ONO5046,EI546,西维来司他,LY544349

Target: Others, SARS-CoV, Serine Protease

Cat.No: T3107

Synonym: AZD9668,Avelestat

Target: Others, Serine Protease

2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one

Cat.No: T8563

Target: Serine Protease

Cat.No: T12613L

Target: Serine Protease

Cat.No: T68099

Synonym: MR-889

Target: Others

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE

Cat.No: T8602

Target: Serine Protease

Cat.No: T10473

Target: Others

Cat.No: T25131

Synonym: AZD 8309,AZD-8309

Target: Glutathione Peroxidase, CXCR

Sivelestat sodium tetrahydrate

Cat.No: T20762

Synonym: ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046

Target: Serine Protease

Cat.No: T15285

Target: Serine Protease

Cat.No: T10254

Target: Serine Protease

Cat.No: T17288

Target: Serine Protease

Cat.No: T31877

Synonym: ONO-PO 736,ONO-6818,ONO 6818,ONO6818

Cat.No: T25520

Synonym: ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355

Cat.No: T25782

Synonym: MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324

Cat.No: T25781

Synonym: MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146

GW311616 hydrochloride

Cat.No: T11525L

Synonym: GW311616A

Target: Others

Cat.No: T69790

Cat.No: T25518

Synonym: Ici186756,Ici--186756

MDL-101146, (R)-

Cat.No: T25784

Synonym: MDL101146, (R)-

Alvelestat tosylate

Cat.No: T3107L

Cat.No: T25521

Synonym: Ici 200,880,Ici-200880,Ici200,880,Ic-200,880,Ici200880

MDL-101146, (S)-

Cat.No: T25784L

Synonym: MDL101146, (S)-

Cat.No: T27747

Synonym: KRP 109,KRP109

Cat.No: T11525

Target: Others

Cat.No: T28244

Synonym: OnoEI601,Ono-EI 601,Ono-EI-601

Cat.No: T41043

Synonym: POL6014

Cat.No: T11865

Synonym: 氯德拉苯,SC-39026,Declaben

Target: Others

Cat.No: T68240

Sivelestat sodium

Cat.No: T21414

Synonym: ONO 5046,LY-544349,Sivelestat sodium salt,ONO-5046,ONO5046,西维来司钠,LY544349,LY 544349

BAY-678 racemate

Cat.No: T19202

Target: Others

MeOSuc-AAPA-CMK

Cat.No: T80553

Freselestat quarterhydrate

Cat.No: T62846

MeOSuc-AAPV-pNA

Cat.No: T38363

Ala-Ala-Pro-Val-chloromethylketone

Cat.No: T72111

Synonym: AAPV-CMK

(R)-BAY-85-8501

Cat.No: T12613

Target: Others

Cat.No: T73657

Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp

Cat.No: T36339

Cat.No: T76248

Lonodelestat TFA

Cat.No: T76216

Cat.No: T10473L

Target: Others

Cathepsin C-IN-6

Cat.No: T79496

Cat.No: T73532

Cat.No: T21989

Cat.No: T80254

Cat. No.	Product Name	Target	Signaling Pathways
TJS0314	5,7-Dihydroxy-4-methylcoumarin Methyl-2H-Chromen-2-One,5,7-二羟基-4-甲基香豆素,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin	Others; Antibacterial; Antifungal	Microbiology/Virology; Others
	5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) 是墨西哥龙蒿中的一种香豆素衍生物。它抑制人类中性粒细胞氧化代谢和弹性蛋白酶活性，有抗真菌和抗细菌活性。
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

5,7-Dihydroxy-4-methylcoumarin

Cat.No: TJS0314

Synonym: Methyl-2H-Chromen-2-One,5,7-二羟基-4-甲基香豆素,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin

Target: Others, Antibacterial, Antifungal

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01773	ELANE Protein, Human, Recombinant (GST) Neutrophil elastase,ELA2,Medullasin,El...	Human	E. coli
	Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae. ELANE Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 52.6 kDa and the accession number is P08246.
TMPY-00672	Azurocidin/CAP37 Protein, Human, Recombinant (His) AZU,NAZC,azurocidin 1,hHBP,AZAMP,HUMAZUR,CAP37,HBP,AZU1	Human	HEK293 Cells
	Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is n...
TMPY-01909	Elafin Protein, Human, Recombinant (His) WAP3,ESI,peptidase inhibitor 3,SKALP,cementoin,MGC13613,WFDC...	Human	HEK293 Cells
	Elafin, also known as Elastase-specific inhibitor, Peptidase inhibitor 3, Protease inhibitor WAP3, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, PI3, WAP3 and WFDC14, is a secreted protein that contains one WAP domain. Elafin / PI3 consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain at the N-terminus serves as an anchor to localize elafin covalently to specific si...

重组蛋白

ELANE Protein, Human, Recombinant (GST)

Cat.No: TMPH-01773

Species: Human

Expression System: E. coli

Azurocidin/CAP37 Protein, Human, Recombinant (His)

Cat.No: TMPY-00672

Species: Human

Expression System: HEK293 Cells

Elafin Protein, Human, Recombinant (His)

Cat.No: TMPY-01909

Species: Human

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼